desktop rez changes/can't access taskbar after playing game w/Wine

[rokytnji]

Might help, might not.

Fullscreen issues with overlapping Panel
Sometimes the Panel overlaps your fullscreen application you're running in wine. If you are running Visual Effects, the first solution you should try is to turn those off: Go to System -> Preferences -> Appearance, and click the Visual Effects tab. Select None, and your screen will flash. Try your full-screen application again. You may re-enable Visual Effects afterwards - just don't forget to turn them back off when you want to run that application again!

from

https://help.ubuntu.com/community/Wine